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董德利教授
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  董德利教授,男,1970年2月生。现为哈尔滨医科大学药理学教研室副主任,哈尔滨医科大学研究生学院副院长。本科毕业于中国药科大学药理学专业,硕士、博士毕业于哈尔滨医科大学药理学专业,曾先后到加拿大卡尔加里大学医学院和美国纽约医学院做访问学者。现为《药学学报》和《Acta Pharmaceutica Sinica B》编委,中国药理学会心血管专业委员会常务委员,曾获全国优秀博士论文,国务院特殊津贴,黑龙江省卫生系统“有突出贡献中青年专家”,龙江学者,黑龙江省优秀教师等荣誉。
  董德利教授一直工作在药理学科研与教学第一线,承担国家自然科学基金等项目17项,目前在Hypertension (3篇), Br J Pharmacol(3篇), Cardiovasc Res, Biomaterials, J Mol Cell Cardiol, Pflügers Archiv等杂志发表第一/通讯作者SCI论文37篇,获授权发明专利4项(第一发明人),获黑龙江省科学技术奖二等奖3项(第一完成人)。有关骨形成蛋白-4与心肌肥厚关系研究发表于Hypertension (2013; 61: 352-360.),并作为编辑推荐(Editor’s Picks)文章,被评为Hypertension杂志基础研究类Top论文奖(2013)。受邀在Channels (Austin),Trends Cardiovasc Med 发表综述。董德利教授研究工作主要方向为病理性心肌肥厚及其诱发心律失常的发生机制,血管功能调节与高血压;在此基础上,开展了药理学和小分子药物开发研究和新型药物递送系统研究。与哈尔滨工程大学合作,研究新型可降解药物载体材料-聚癸二酸甘油醇酯弹性体,发表于生物医用材料领域国际专业杂志Biomaterials。


    董德利教授目前发表第一/通讯作者SCI论文如下:
  1.Sun B, Huo R, Sheng Y, Li Y, Xie X, Chen C, Liu HB, Li N, Li CB, Guo WT, Zhu JX, Yang BF, Dong DL. Bone Morphogenetic Protein-4 Mediates Cardiac Hypertrophy, Apoptosis, and Fibrosis in Experimentally Pathological Cardiac Hypertrophy. Hypertension. 2013; 61: 352-360.
  2.Dong DL, Chen C, Huo R, Wang N, Li Z, Tu YJ, Hu JT, Chu X, Huang W, Yang BF. Reciprocal Repression between MicroRNA-133 and Calcineurin Regulates Cardiac Hypertrophy: A Novel Mechanism for Progressive Cardiac Hypertrophy. Hypertension. 2010;55:946-952.
  3.Dong DL, Zhang Y, Lin DH, Chen J, Patschan S, Goligorsky MS, Nasjletti A, Yang BF, Wang WH. Carbon Monoxide Stimulates the Ca2+–activated Big Conductance K (BK) Channels in Cultured Human Endothelial Cells. Hypertension 2007,50:643-651.
  4.Xie X, Zhao Y, Ma CY, Xu XM, Zhang YQ, Wang CG, Jin J, Shen X, Gao JL, Li N, Sun ZJ, Dong DL. Dimethyl fumarate induces necroptosis in colon cancer cells through glutathione depletion/ROS increase/MAPKs activation pathway. Br J Pharmacol. 2015 May 8. doi: 10.1111/bph.13184. [Epub ahead of print]. 
  5.Wang YC, Xiao XL, Li N, Yang D, Xing Y, Huo R, Liu MY, Zhang YQ, Dong DL. Estrogen inhibits BMP4-induced BMP4 expression in cardiomyocytes: a potential mechanism of estrogen-mediated protection against cardiac hypertrophy. Br J Pharmacol. 2014 Oct 17. doi: 10.1111/bph.12983. [Epub ahead of print]
  6.Sheng Y, Sun B, Guo WT, Liu X, Wang YC, Xie X, Xiao XL, Li N, Dong DL. DMH1 (4-[6-(4-Isopropoxyphenyl)pyrazolo [1,5-a]pyrimidin-3-yl] quinoline) is a novel autophagy inhibitor. Br J Pharmacol. 2014 Nov;171(21):4970-80.
  7.Bai YL, Liu HB, Sun B, Zhang Y, Li Q, Hu CW, Zhu JX, Gong DM, Teng X, Zhang Q, Yang BF, Dong DL. HIV Tat protein inhibits hERG K+ channels: a potential mechanism of HIV infection induced LQTs. J Mol Cell Cardiol. 2011;51(5):876-80.
  8.Guo WT, Dong DL. Bone morphogenetic protein-4: a novel therapeutic target for pathological cardiac hypertrophy/heart failure. Heart Fail Rev. 2014;19(6):781-8.
  9.Hu CW, Li Q, Zhang Y, Li YH, Jiang HC, Liu MY, Li SL, Han W, Dong DL. Bone morphogenetic protein-4 induces upregulation of Cav3.1 Ca2+ channels in HL-1 atrial myocytes. Pflugers Arch. 2014;466(11):2049-57. 
  10.Lu J, Sun B, Huo R, Wang YC, Yang D, Xing Y, Xiao XL, Xie X, Dong DL. Bone morphogenetic protein-2 antagonizes bone morphogenetic protein-4 induced cardiomyocyte hypertrophy and apoptosis. J Cell Physiol. 2014; 229: 1503–1510.
  11.Li Q, Zhang Y, Sheng Y, Huo R, Sun B, Teng X, Li N, Zhu JX, Yang BF, Dong DL. Large T antigen up-regulates Kv4.3 K+ channels through Sp1 and Kv4.3 K+ channels contribute to cell apoptosis and necrosis through activation of calcium/calmodulin-dependent protein kinase II. Biochem J. 2012,441(3): 859-867.
  12.Huo R, Sheng Y, Guo WT, Dong DL. The potential role of Kv4.3 K+ channel in heart hypertrophy. Channels (Austin). 2014 Apr 24;8(3).
  13.Xie X, Xu XM, Li N, Zhang YH, Zhao Y, Ma CY, Dong DL. DMH1 Increases Glucose Metabolism through Activating Akt in L6 Rat Skeletal Muscle Cells. PLoS One. 2014;9(9):e107776.
  14.Deli Dong, Yanjun Duan, Jiqingguo, Dan E. Roach, Shauni L Swirp, Li Wang, J.P.Lees-Miller, R.S.Sheldon, Jeffery D. Molkentin, Henry J Duff. Overexpression of Calcineurin in Mouse Ventricle Causes Sudden Cardiac Death Associated with Decreased Density of K+ Channels. Cardiovascular Research 2003;57:320-332.
  15.Hui-Bin Liu, Bao-Feng Yang, De-Li Dong. Calcineurin and electrical remodeling in pathological cardiac hypertrophy. Trends in Cardiovascular Medicine 2010; 20: 148-153.
  16.Xing Y, Yang D, Lu J, Dong DL. Insulin prevents bone morphogenetic protein-4 induced cardiomyocyte apoptosis through activating Akt. Biochem Biophys Res Commun. 2015 ;456(2):605-9.
  17.Wang YC, Hu CW, Liu MY, Jiang HC, Huo R, Dong DL. Copper induces vasorelaxation and antagonizes noradrenaline-induced vasoconstriction in rat mesenteric artery. Cell Physiol Biochem. 2013;32(5):1247-54.  
  18.Sun B, Sheng Y, Huo R, Hu CW, Lu J, Li SL, Liu X, Wang YC, Dong DL. Bone morphogenetic protein-4 contributes to the down-regulation of Kv4.3 K+ channels in pathological cardiac hypertrophy. Biochem Biophys Res Commun. 2013;436(4):591-4.
  19.Sheng Y, Sun B, Guo WT, Zhang YH, Liu X, Xing Y, Dong DL. 3-methlyadenine induces cell death and its interaction with chemotherapeutic drugs is independent of autophagy. Biochem Biophys Res Commun. 2013;432(1):5-9.
  20.Sun ZJ, Chen C, Sun MZ, Ai CH, Lu XL, Zheng YF, Yang BF, Dong DL. The application of poly (glycerol-sebacate) as biodegradable drug carrier. Biomaterials. 2009,30(28):5209-5214.
  21.Chang Chen, Rong Huo, Yan Tong, Hui-Bin Liu, Yue Sheng, Xu Gao, Osamu Nakajima, Bao-Feng Yang, De-Li Dong. Systemic Heme Oxygenase-1 Transgenic Overexpression Aggravates Pressure Overload-induced Cardiac Hypertrophy in Mice. Cell Physiol Biochem. 2011;28:25-32.
  22.Rong Huo, Zhe Li, Cui-Cui Lu, Yan Xie, Bin Wang ,Yu-Jie Tu , Jun-Tao Hu, Chang-Qing Xu, Bao-Feng Yang, De-Li Dong. Inhibition of 2-Aminoethoxydiphenyl borate-induced Rat Atrial Ectopic Activity by Anti-arrhythmic Drugs. Cellular Physiology and Biochemistry 2010, 25;425-432.
  23.De-Li Dong, Peng Yue, Bao-Feng Yang, Wen-Hui Wang. Hydrogen peroxide stimulates the Ca2+-activated big-conductance K channels (BK) through cGMP signaling pathway in cultured human endothelial cells. Cellular Physiology and Biochemistry 2008;22:119-126.
  24.Hu CW, Sheng Y, Zhang Q, Liu HB, Xie X, Ma WC, Huo R, Dong DL. Curcumin inhibits hERG potassium channels in vitro. Toxicol Lett. 2012;208(2):192-6.
  25.Gao X, Liu HB, Wu JC, Liang J, Zhou LY, Zhao LL, Chen C, Tong Y, Gong DM, Nakajima O, Yang BF, Dong DL. Heme oxygenase-1 transgenic overexpression did not prevent artery injury induced by electric stimulation and pressure overload in mice. European Journal of Pharmacology 2011;659:199-205.
  26.Chang Chen, Jun-Tao Hu, Yu-Jie Tu, Ji-Chao Wu, Jing Liang, Li-Ling Gao, Zhi-Guo Wang, Bao-Feng Yang, De-Li Dong. Effects of isosorbide mononitrate on the restoration of injured artery in mice in vivo. European Journal of Pharmacology. 2010;640:150-156.
  27.Dong DL, Chen C, Huang W, Chen Y, Zhang XL, Li Z, Li Y, Yang BF. Tricarbonyldichlororuthenium (II) dimer (CORM2) activates non-selective cation current in human endothelial cells independently of carbon monoxide releasing. European Journal of Pharmacology. 2008 ;590(1-3):99-104.
  28.De-Li Dong, Qing-Hui Wang, Peng Yue, Jun-Dong Jiao, Rui-Min Gu, Bao-Feng Yang. Indapamide induces apoptosis of GH3 pituitary cells independently of its inhibition of voltage-dependent K+ currents. European Journal of Pharmacology 2006, 536(1-2), 78-84.
  29.De-Li Dong, Yan Luan, Tie-Ming Feng, Chang-Long Fan, Peng Yue, Zhi-Jie Sun, Rui-Min Gu, Bao-Feng Yang. Chlorzoxazone inhibits contraction of rat thoracic aorta. European Journal of Pharmacology 2006, 545(2-3),161-166.
  30.De-Li Dong, Qing-Hui Wang, Wei Chen, Jiao-Jie Fan, Jing-Wei Mu, Jia Ke, Bao-Feng Yang. Contrasting effects of tetraethylammonium and 4-aminopyridine on the gastrointestinal function of murine. European Journal of Pharmacology 2005, 509(2-3), 179-185.
  31.Zhe Li, Zhi-Lin Xu, Jing Liang, Ji-Chao Wu, Qin Zhang, Hui Xie, Wen-Chao Ma, Hong-Chi Jiang, Bao-Feng Yang, De-Li Dong. Tetraethylammonium enhances the rectal and colonic motility in rats and human in vitro. Naunyn Schmiedebergs Arch Pharmacol. 2011;384(2):147-55.
  32.DONG De-Li, LIU Yan, ZHOU Yu-Hong, SONG Wei-Hua, WANG He, YANG Bao-Feng. Decreases of voltage-dependent K+ currents densities in ventricular myocytes of guinea pigs by chronic oxidant stress in vitro. Acta Pharmacologica Sinica 2004, 25.(6)751-755.
  33.De-Li DONG, Zhe LI, Hui-Zhen WANG, Zhi-Min DU, Wei-Hua SONG, Bao-Feng YANG. Acidification alters antiarrhythmic drug blockade of the human HERG channels. Basic & Clinical Pharmacology & Toxicology 2004;94:209-212.
  34.Zhi-Jie Sun, Lan Wu, Wei Huang, Chang Chen, Yan Chen, Xi-Li Lu, Xiao-Lan Zhang, Bao-Feng Yang, De-Li Dong. Glycolic acid modulates the mechanical property and degradation of poly(glycerol, sebacate, glycolic acid). Journal of Biomedical Materials Research Part A. 2010;92(1):332-9.
  35.Zhi-Jie Sun , Lan Wu , Wei Huang, Xiao-Lan Zhang, Xi-Li Lu, Yu-Feng Zheng, Bao-Feng Yang, De-Li Dong. The influence of lactic on the properties of Poly (glycerol–sebacate–lactic acid). Materials Science and Engineering C, 2009;29 : 178–182.
  36.Zhi-Jie Sun , Bo Sun, Cheng-Wu Sun, Li-Bo Wang, Xin Xie, Wen-Chao Ma, Bao-Feng Yang, De-Li Dong. A poly (glycerol-sebacate-(5-fluorouracil-1-acetic acid)) polymer with potential use for cancer therapy. Journal of Bioactive and Compatible Polymers 2012; 27: 18-30.
  37.Sun ZJ, Sun B, Tao RB, Xie X, Lu XL, Dong DL. A poly(glycerol-sebacate-curcumin) polymer with potential use for brain gliomas. J Biomed Mater Res A. 2013;101(1):253-60.

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